Main Research

The main scientific interest of the Ullrich lab focuses on cellular immunology and immunoregulation of immune deficiencies, malignant diseases, cancer therapy and stem cell transplantation.

Preclinical studies aim to characterize specific functions and the complex interactions of subsets of T cells, dendritic cells (DC), natural killer (NK), cytokine induced killer (CIK) and innate lymphoid cells (ILCs).

In the field of translational research, the Ullrich lab performs immunomonitoring studies of cancer patients undergoing specific treatments, autologous or allogeneic stem cell transplantation.

Projects with focus on immunoregulation of graft-versus-leukemia (GVL) and graft-versus-host (GVH) effects in allogeneic stem cell transplantation have been supported by the German Cancer Aid as Max Eder Research Group and awarded with different international research prizes.

Beyond standard methods of molecular and cell biology, the Ullrich lab is specialized in flow cytometry, cell sorting and advanced in vitro and in vivo imaging methods.

By use of these varieties of technics, the group aims to improve the activation and migration of adoptively transferred immune subsets for the optimization of cellular therapeutic protocols.

The overall research aims are the optimization of personalized cellular therapy combined with immunomodulation in patients with advanced malignant diseases.
 

Team:

Sara Tognarelli, Jochen Früh, Nina Staiger, Benedikt Jacobs,
Annekathrin Heinze, Bushra Rais, Kyra Fischer, Kathrin Trefzer, Evelyn Ullrich, Juliane Wagner (from top left to bottom right)

Funding:

• LOEWE Center for Cell and Gene Therapy Frankfurt (CGT)
• German Cancer Aid
• Wilhelm Sander Foundation
  
  

Alumni (in alphabetical order):

Dr. Ruth Bauer, Dr. Karina Bösl, Franziska Ganss, Dr. Konrad Geisler, Dr. Stephanie Gerstner, Dr. Benedikt Jakobs, Dr. Irena Kröger, Dr. Friederike Mayer, Dr. Kathrin Meinhardt, Dr. Jennifer Möckl, Dr. Ilja Ovsiy, Viktoria Pfannenstiel, Dr. Anna Reischer, Dr. Johanna Rothamer, Julia Schneider, Catharina Worm

International Cooperations:

Prof. A. Beilhack, Medizinische Klinik II, Universitätsklinikum Würzburg
Prof. D. Dudziak, Dermatologie, Friedrich-Alexander-Universität Erlangen
Prof. A. Mackensen, Medizinische Klinik 5, Friedrich-Alexander-Universität Erlangen
Prof. R. Zeiser, Klinik für Innere Medizin I, Albert-Ludwigs-Universität Freiburg
Prof. L. Zitvogel, Institut Gustave Roussy, Paris-Villejuif

Open positions:

We offer positions for MD and PhD students and encourage you to send an application to join our team.
Contact: Prof. Dr. Evelyn Ullrich