An effective strategy to prevent relapse after allogeneic stem cell transplantation in children with ALL
Mixed chimerism (MC) and Minimal Residual Disease (MRD) strongly predict relapse in children with ALL after allo-SCT. Pre-emptive immunotherapy (IT), e.g. withdrawal of immunosuppression (WD-IS) or Donor Lymphocyte Infusion (DLI) can prevent impending relapse. We retrospectively analyzed chimerism and MRD monitoring and the effect of pre-emptive IT.